Susan Bukata, MD
Chair, Department of Orthopedic + Surgery, UC San Diego
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A New Way to Keep Your Patients Standing Strong
Become a Practitioner Partner, and bring the first plant-sourced synbiotic clinically proven to preserve bone density to patients who need it most.
CLINICALLY TESTED + PEER REVIEWED • PUBLISHED IN OSTEOPOROSIS INTERNATIONAL • #1 PRACTITIONER RECOMMENDED SYNBIOTIC MEDICAL FOOD • GENTLE + SAFE • SUPPORTS GUT + IMMUNE HEALTH FUNCTION •
CLINICALLY TESTED + PEER REVIEWED • PUBLISHED IN OSTEOPOROSIS INTERNATIONAL • #1 PRACTITIONER RECOMMENDED SYNBIOTIC MEDICAL FOOD • GENTLE + SAFE • SUPPORTS GUT + IMMUNE HEALTH FUNCTION •
Finally—A Small Daily Habit That Makes a Measurable Difference
Together, we can close the long-overlooked gap in women’s bone health with a rigorously tested, scientific breakthrough.
The Landmark CLINICAL Trial (2025)
As a medical food, Bōndia is held to standards far beyond those applied to supplements. In fact, our landmark study voluntarily met the most stringent clinical design:
A 12-month, randomized, double-blind, placebo-controlled trial of 286 postmenopausal women—peer-reviewed and published in Osteoporosis International.
The results were striking. Bōndia improved bone density outcomes dramatically in three high-risk groups, slowing bone loss by 85% in women with osteopenia, 75% in women with BMI ≥30, and 60% in women with ≥40% body fat.
VIEW THE WHITEPAPER
Schott EM et al. Osteoporos Int. 2025;36(10):2019-2030.
SAFETY + PRECISION
Bōndia is a remarkably safe way to proactively maintain bone density without the health risks and side effects often seen with medications.. Mild bloating or gas is normal in the first few days, subsiding as your gut microbiome adjusts to the remarkably well-tolerated formula. And that’s it. No more side effects.
D. Davidson Easson Jr., Vincent A. Murphy, Alicia E. Ballok, Maria J. Soto-Giron, Eric M. Schott, Joseph Rodricks, Gerardo V. Toledo. Food safety assessment and toxicity study of the synbiotic consortium SBD111. Food and Chemical Toxicology Volume 168, October 2022, 113329
Bōndia’s formulation is intentionally streamlined. Its four strains were selected because the empirical data showed something novel: they work better together than they do on their own.
This matters. For any two bacterial strains, the likelihood of a negative interaction is 2.5X higher than a positive one. In other words, more strains don’t necessarily mean more benefit; each additional strain of good bacteria makes negative interactions more likely.
That’s why multistrain probiotics with large lists of ingredients—even those with 20+ strains—aren’t inherently more powerful. Bōndia uses fewer strains by design, prioritizing synergy, stability, and predictable clinical effect, so you can offer your patients something that actually supports the gap you see every day in midlife bone loss. The precision-release capsule design shields living cultures from stomach acid, so they make it to where they’re needed most—alive and active.
Bōndia is more than a dietary supplement; it’s a medical food held to higher safety and efficacy standards. Our testing goes beyond regulatory minimums, verifying purity and potency at every stage of development. Four capsules a day bridge the interventions gap and complement your clinical care.
Schott, E.M.; Charbonneau, M.R.; Kiel, D.P.; Bukata, S.; Zuscik, M.J.; Rosen, C.; Ballok, A.; Toledo, G.V.; Steels, E.; Huntress, H.; et al. A Randomized, Double-Blind, Placebo-Controlled Clinical Study to Evaluate the Efficacy of the Synbiotic Medical Food, SBD111, for the Clinical Dietary Management of Bone Loss in Menopausal Women. Osteoporos Int 2025, doi:10.1007/s00198-025-07650-7.
WHO IS BŌNDIA FOR?
The short answer: women and many of the patients you know are at risk or already experiencing bone loss.*
You see it all the time: women blindsided by their first DEXA scan. Yet the interventions available between “monitor it” and “medicate it” have been limited—until now.
In our landmark study of 286 postmenopausal women, Bōndia significantly improved bone loss outcomes in women with osteopenia, elevated BMI, and higher body fat composition—three groups at some of the highest risk for fragility fractures. In fact, 80% of women over 50 are in one or more of the groups that Bōndia is clinically proven to protect.
Reid IR et al. Lancet Diabetes Endocrinol. 2024;12:856-864.
As a medical food, Bōndia is HSA/FSA eligible without the artificially inflated drug costs that leave many patients—especially the underinsured—without accessible options.
Men also experience age-related bone loss driven by inflammation and increased osteoclast activity. Bondia, although not clinically studied in men, may support their bone health as well.
*We recognize the full spectrum of gender identity. In this clinical context, “women” includes cis women and most people assigned female at birth, whose biology places them at higher risk for bone loss.
BONE + GUT BENEFITS
In gold-standard clinical trials—a level of rigor rarely seen (and never required) in supplements—Bōndia dramatically reduced bone loss in women with osteopenia, elevated BMI (≥30), or higher body fat composition (≥40%). The long-term implications are striking: osteopenic women stand to lose as much bone in a single year as those taking Bōndia may lose in over six.
Beyond these groundbreaking bone density results, Bōndia also supported digestive gut health. Women in the landmark study experienced the strongest improvements in severe nausea, constipation, gas, and bloating, with these gut symptoms reduced by 78.9%.
Schott EM et al. Osteoporos Int. 2025;36(10):2019-2030.
MECHANISM OF ACTION
Think of Bōndia as working from the gut outward, specifically targeting the gut-bone axis.
The synbiotic formulation strengthens intestinal barrier integrity, limiting translocation of inflammatory molecules into the bloodstream. In parallel, it enriches microbial populations that generate short-chain fatty acids and neurotransmitters like GABA, dopamine, and serotonin.These metabolites promote anti-inflammatory immune responses.
Importantly, Bōndia reduces immune inflammatory response signaling, including IL-6, IL-8 and IFN-γ. The resulting decrease in systemic inflammation reduces osteoclast activity. This is particularly relevant for people going through menopause, when declining estrogen accelerates osteoclast-driven bone resorption. By calming inflammatory signaling, Bōndia helps dramatically slow this process.
Green RS et al. J Funct Foods. 2025;135:107114. Lawneius L et al. Am J Physiol Endocrinol Metab. 2022;322(4):E344-E354.
REFRIGERATED FOR A REASON
Bōndia is temperature-controlled because it’s alive and designed to stay that way—95 billion CFUs of active probiotic cultures (and the fiber-rich prebiotic fuel they need to thrive) that actually reach your gut to do their job. While Bōndia should be kept refrigerated for long-term storage, it’s shelf-stable for up to 90 days (≤ 77°F), making it easy for patients to travel with Bōndia.
Our testing goes beyond regulatory minimums, verifying purity, potency, and biocompatibility at every stage of development.
SAFETY + PRECISION
Bōndia is a remarkably safe way to proactively maintain bone density without the health risks and side effects often seen with medications. Mild bloating or gas is normal in the first few days, subsiding as your gut microbiome adjusts to the remarkably well-tolerated formula.
Easson D. Davidson, et al. SBD111. Food and Chemical Toxicology Volume 168, October 2022, 113329.
Bōndia’s formulation is intentionally streamlined. Its four strains were selected because the empirical data showed something novel: they work better together than they do on their own.
This matters. For any two bacterial strains, the likelihood of a negative interaction is 2.5X higher than a positive one. In other words, more strains don’t necessarily mean more benefit; each additional strain of good bacteria makes negative interactions more likely.
Kehe J et al. Sci Adv. 2021;7(45).
That’s why multistrain probiotics with large lists of ingredients—even those with 20+ strains—aren’t inherently more powerful. Bōndia uses fewer strains by design, prioritizing synergy, stability, and predictable clinical effect, so you can offer your patients something that actually supports the gap you see every day in midlife bone loss.
The precision-release capsule design shields living cultures from stomach acid, so they make it to where they’re needed most—alive and active.
Bōndia is more than a dietary supplement; it’s a medical food held to higher safety and efficacy standards. Our testing goes beyond regulatory minimums, verifying purity and potency at every stage of development. Four capsules a day bridge the interventions gap and complement your clinical care.
Schott EM et al. Osteoporos Int. 2025;36(10):2019-2030.
8 Ingredients. That's It.
Sometimes the simplest, safest sources deliver breakthrough results.
Bōndia’s proprietary, synergistic blend of prebiotics and 95 billion CFUs of probiotics are made up of 8 total ingredients sustainably sourced from just 5 nourishing plants and fermented foods:
- Levilactobacillus brevis SBS04254 : a probiotic from squash
- Leuconostoc mesenteroides SBS04255 : a probiotic from squash
- Pichia kudriavzevii SBS04263 : probiotic yeast from fermented pepper paste
- Lactiplantibacillus plantarum SBS04260 : a probiotic from fermented pepper paste
- Powdered Organic Blueberry: a prebiotic rich in fiber and antioxidants
- Oligofructose: prebiotic fiber from chicory root
- Vitamin D3 (Cholecalciferol): sourced from nutrient-dense marine algae
- Vegetable-Based Capsule: made from plant cellulose (hypromellose)
95 Billion CFUs
Clinically Tested + Proven
Protects Bone Density
Supports gut + immune function
Vegan, Allergen-Free, Non-GMO
See the Science for Yourself
Our randomized, double-blind, placebo-controlled, peer-reviewed results speak for themselves.
See the Science for Yourself
Our randomized, double-blind, placebo-controlled, peer-reviewed results speak for themselves.
It’s Time to Close the Care Gap for Menopausal Bone Loss
Biology gives men a leg up. They start with denser bones and lose bone far more slowly. Women don’t get that luxury. The biology of menopause simply hits harder.
Bōndia is filling this gap in human biology, because women’s quality of life depends on it.
WHITEPAPER LEAD TO COME
Give Women the Power to Save Their Skeletons
Addresses A Treatment Gap
Many women avoid or delay the use of harsh bone drugs. Bōndia offers a safe and natural way to preserve bone density before the need to consider bone strengthening medications arises.
Designed for Confident, Long-Term Use
No black box warnings, no drug interactions, and strong tolerability. Bōndia is the game changer you can recommend with confidence.
Compliments Your Standard of Care
Bōndia may be taken alongside other therapies, including HRT and bone strengthening medications, to extend skeletal protection.
Empowers Proactive Intervention
For at-risk women, Bōndia lets you intervene sooner—when treatment and preservation options are otherwise limited.
Become A Practitioner Partner
APPLY TODAY
STEP 1
Apply for Access
Share a few details about your practice to unlock empowering tools and benefits for you and your patient community.
STEP 2
Create Your Account
Once approved, set up your profile and gain access to exclusive patient discounts, clinical resources, community events, wholesale pricing, and the option to earn commission if it aligns with your practice.
STEP 3
Rewrite What’s Possible for Bone Health
Help your patients preserve skeletal strength and overall vitality with Bondia—and stay connected as we expand microbiome solutions for more underserved inflammatory conditions.
Team Bōndia in Action
Come Meet Us!
Nutrition Conference 2026
Four days of evidence-informed educational sessions, interactive workshops, and pre-conference
seminars with internationally recognized researchers and clinicians.
CONNECT WITH US
Clinician POV
Dr. Robin Berzin, Founder of Parsley Health
Dr. Robin Berzin talks about her plan to reverse her osteopenia, including upping her strength
training regime and taking Bōndia.
WATCH
NOW
Clinical Review
Dr. Doug Lucas reviews Bōndia clinical study
The discussion highlights Bōndia's unique formulation, its impact in postmenopausal women, and why
body composition matters, especially for women with osteopenia and higher BMI.
LEARN
MORE
An Expert Collective
Our Clinical + Scientific
Guides
Mark Charbonneau, PHD
Vice President of Research & Development, Sōlaria Biō +Washington University in St. Louis, PhD, Computational and Systems Biology
Amy Stanbery
Co-Founder at DexaFit, Inc + Netflix "You Are What You Eat" + Advisor at Podium Fit & Sōlaria Biō
Alicia Ballok, PHD
Director, Discovery, Sōlaria Biō + Geisel School of Medicine at Dartmouth, PhD, Microbiology and Immunology
Michael Zuscik, PhD
Mack Clayton Professor & Vice Chair of Research, Department of Orthopedics, University of Colorado Anschutz Medical Campus + Director of the Colorado Program for Skeletal Research
Peter Barton Hutt
Senior Counsel, Covington & Burling LLP + Former FDA General Counsel, Author of Medical Foods regulations
Eric Schott, PHD
Co-Founder & Chief Operating Officer, Sōlaria Biō + University of Rochester Medical School, PhD, Cell Biology of Human Disease
AN EXPERT COLLECTIVE
Our Clinical + Scientific Guides
Your Patients’ Bones Will Thank You
Join a community of forward-thinking providers determined to close the care gap and champion long-term bone health.
PARTNER WITH US
How Bōndia Works
MONTHS 1-4
Your Body Begins to Respond
Within days, Bōndia's good bacteria begin calming the inflammation that contributes to bone loss. Your body absorbs algae-derived Vitamin D3, while Bōndia's synergistic microbes naturally produce vitamin K2—a perfect pair that helps your bones retain calcium.
At the cellular level, your osteoclasts (cells that break down old bone) and osteoblasts (cells that build new bone) start to rebalance. Mild bloating or gas is normal in the first few days—usually fading quickly as your gut microbiome finds renewed equilibrium.
MONTHS 5-9
Protection Takes Hold
Your gut and bone systems are now in sync. Bōndia's revolutionary synbiotic formulation helps slow the bone-degrading activity of osteoclasts, supporting a healthier balance between bone breakdown and renewal.
Clinical studies show measurable protection against bone loss during this phase, and participants report improved digestion as microbial diversity stabilizes.
MONTHS 10-12+
Sustained Strength
With consistent use, Bōndia continues to support a steady, healthy rhythm of bone turnover as osteoblasts are able to keep better pace with osteoclasts. Your gut and immune systems are more resilient, digestion is smoother, and your foundation for long-term strength is stronger than before.
Bone health isn't a sprint—it's a lifelong rhythm. Bōndia helps keep that rhythm in balance, protecting your bones from the inside out.
The Future of Bone Health Is in Your Hands
As a Practitioner Partner, you’ll receive clinical guidance tools, community event access, exclusive patient discounts, and the option to earn commission if it aligns with your practice.
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REQUEST SAMPLES
Estrogen-Free • Estrogen-Free • Allergen-Free • Low FODMAP • Vegan • Gluten-Free • Non-GMO • 100% Fruit + Vegetable + Fermented Food Based • Clinically Proven • Gold-Standard Scientific Rigor •
Estrogen-Free • Allergen-Free • Low FODMAP • Vegan • Gluten-Free • Soy-Free • Non-GMO • 100% Fruit + Vegetable + Fermented Food Based • Clinically Proven • Gold-Standard Scientific Rigor •
Estrogen-Free • Allergen-Free • Low FODMAP • Vegan • Gluten-Free • Soy-Free • Non-GMO • 100% Fruit + Vegetable + Fermented Food Based • Clinically Proven • Gold-Standard Scientific Rigor •
Estrogen-Free • Allergen-Free • Low FODMAP • Vegan • Gluten-Free • Soy-Free • Non-GMO • 100% Fruit + Vegetable + Fermented Food Based • Clinically Proven • Gold-Standard Scientific Rigor •
Estrogen-Free • Estrogen-Free • Allergen-Free • Low FODMAP • Vegan • Gluten-Free • Non-GMO • 100% Fruit + Vegetable + Fermented Food Based • Clinically Proven • Gold-Standard Scientific Rigor •
Estrogen-Free • Allergen-Free • Low FODMAP • Vegan • Gluten-Free • Soy-Free • Non-GMO • 100% Fruit + Vegetable + Fermented Food Based • Clinically Proven • Gold-Standard Scientific Rigor •
Estrogen-Free • Allergen-Free • Low FODMAP • Vegan • Gluten-Free • Soy-Free • Non-GMO • 100% Fruit + Vegetable + Fermented Food Based • Clinically Proven • Gold-Standard Scientific Rigor •
Estrogen-Free • Allergen-Free • Low FODMAP • Vegan • Gluten-Free • Soy-Free • Non-GMO • 100% Fruit + Vegetable + Fermented Food Based • Clinically Proven • Gold-Standard Scientific Rigor •
How does Bōndia compare to standard supplemental support for bone loss like calcium and vitamin D?
Calcium and vitamin D provide basic nutrients for bone health, but large studies show they have limited impact on slowing bone loss. Bōndia works through a different pathway by reducing inflammation and slowing bone breakdown via the gut–bone connection. In a year-long randomized, placebo-controlled study in postmenopausal women, Bōndia helped slow bone loss beyond vitamin D alone and was well-tolerated, making it a complementary option with lifestyle modifications and/or bone-building medications.
How does Bōndia compare to bone strengthening medications and other bone building/supporting medications?
Bisphosphonates and other osteoporosis drugs directly affect bone cells to reduce fracture risk or build new bone and are used to treat diagnosed osteoporosis. Bōndia is a medical food that supports bone health by reducing inflammation and slowing bone breakdown through the gut–bone connection. It does not replace prescription medications but may be used as a supportive/complementary option, under the guidance of a healthcare provider.
Can Bōndia be taken alongside hormone replacement therapy?
Bōndia works through the gut and immune system to reduce inflammation and slow bone breakdown, which is different from how HRT supports bone by replacing estrogen. Because their mechanisms are different, Bōndia may be used as a complementary approach to support bone health alongside HRT, with guidance from your healthcare provider.
How can I recommend Bōndia to my patients?
We have several ways to recommend Bōndia to your patients. You can request patient samples here that contain a QR code directing patients to solaria.bio, along with a patient coupon for optimal pricing. You can sign up here to create a wholesale account to distribute products directly from your office, as well as receive a free affiliate link to share with patients that offers a 10% discount on their initial online order. It's ideal for refills and for offering discounted subscriptions to support long-term adherence to your protocol.
How and when should patients take Bōndia?
Bōndia was shown to be effective when taken twice daily. This allows the probiotics to remain active in your system throughout the day, ensuring optimal interaction with your bone health and aligning with the regimen followed in Bōndia’s trials. To help maintain this consistency, we recommend setting a reminder to take Bōndia each day.
Bōndia can be taken with or without food. Some people experience mild GI discomfort when consuming medications or supplements on an empty stomach. To help you get the most out of your routine, here’s a quick tip for getting started:
Week 1: Take 1 capsule with breakfast and 1 capsule with dinner.
Week 2 and beyond: Take 2 capsules with breakfast and 2 capsules with dinner.
How does Bōndia support bone health during menopause?
After menopause, lower estrogen levels can increase inflammation and bone breakdown. Bōndia helps address this by reducing inflammation and slowing bone resorption through the gut–bone connection.
What makes Bōndia different from other probiotics or synbiotics?
Bōndia contains specific plant-derived probiotic strains proprietary to Sōlaria Biō and prebiotics selected for their ability to support gut barrier function, reduce inflammation, and influence bone-related immune signaling.
Why does gut health matter for bone health?
The gut plays an important role in regulating inflammation and immune signals that affect bone breakdown. Supporting gut health can help reduce inflammatory signals that contribute to bone loss.
Is Bōndia helpful for people on Aromatase Inhibitors?
Aromatase inhibitors are commonly used in breast cancer treatment, but they can cause significant bone loss. Therefore, patients on these medications must be closely monitored by their healthcare provider. Regular monitoring of bone density is important, as these patients may require additional bone-protective therapy to prevent osteoporosis or fractures.
Bōndia does not contain estrogen or progesterone (non-hormonal), making it safe for patients taking aromatase inhibitors.
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